2490589-12-1
Chemical Structure
sEH/AChE-IN-4
- CAS No.: 2490589-12-1
- Formula:C35H39ClF3N5O3
- Molecular Weight:670.16
IUPAC Name: 1-(1-(5-(((7R,11R)-3-chloro-9-methyl-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-12-yl)amino)pentanoyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
InChIKey: VPHLBLQNXMWQOL-PKTZIBPZSA-N
SMILES: O=C(N1CCC(CC1)NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CCCCNC3=C4C(C[C@H]5C[C@@H]4CC(C)=C5)=NC6=CC(Cl)=CC=C63
Biological Activity: sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].
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sEH/AChE-IN-4 | sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively. | |||||||||||||||||||||
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Keywords
