Kuwanon U
Based on 1 Customer Validation
Kuwanon U is a potent cholinesterase inhibitor with IC50s of 19.69, 10.11 µM and Kis of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD).
For research use only. We do not sell to patients.
- Purity: 97.30%
- CAS No.: 123702-95-4
- Formula: C26H30O6
- Molecular Weight:438.51
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
AChE 19.69 μM (IC50) |
AChE 6.48 μM (IC50) |
BChE 10.11 μM (Ki) |
BChE 9.59 μM (Ki) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BJ | EC50 |
>10 μM
Compound: 14
|
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
|
[PMID: 20192247] |
| CCRF-CEM | EC50 |
>10 μM
Compound: 14
|
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
|
[PMID: 20192247] |
| HeLa | EC50 |
>10 μM
Compound: 14
|
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
|
[PMID: 20192247] |
| MCF7 | EC50 |
>10 μM
Compound: 14
|
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
|
[PMID: 20192247] |
| RPMI-8226 | EC50 |
>10 μM
Compound: 14
|
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
|
[PMID: 20192247] |
| SR | IC50 |
35.62 μM
Compound: Kuwanon U
|
Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay
Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay
|
[PMID: 32435418] |
| THP-1 | EC50 |
>10 μM
Compound: 14
|
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
|
[PMID: 20192247] |
| U-266 | EC50 |
>10 μM
Compound: 14
|
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
|
[PMID: 20192247] |
Chemical Information
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CAS No. 123702-95-4
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Appearance Solid
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Molecular Weight 438.51
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Formula C26H30O6
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Color Off-white to light yellow
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SMILES
O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(C/C=C(C)/CC/C=C(C)\C)=C(C=C3O)OC)C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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