H3R antagonist 2
H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R . H3R antagonist 2 shows inhibitory effects with IC50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB.
For research use only. We do not sell to patients.
- CAS No.: 2970985-05-6
- Formula: C24H29NO3
- Molecular Weight:379.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
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human H3 receptor 170 nM (Ki) |
Acetylcholinesterase 180 nM (IC50) |
MAO-B 775 nM (IC50) |
Butyrylcholinesterase 880 nM (IC50) |
Chemical Information
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CAS No. 2970985-05-6
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Molecular Weight 379.49
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Formula C24H29NO3
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SMILES
O=C1C2=CC(OCCCCCN3CCCCCC3)=CC=C2OC4=C1C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H3R antagonist 2 Related Classifications
HY-146383 Related Classifications
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