2970985-05-6
Chemical Structure
H3R antagonist 2
- CAS 番号: 2970985-05-6
- Formula:C24H29NO3
- Molecular Weight:379.49
IUPAC Name: 2-((5-(azepan-1-yl)pentyl)oxy)-9H-xanthen-9-one
InChIKey: KNIPHGXUVWAHCN-UHFFFAOYSA-N
SMILES: O=C1C2=CC(OCCCCCN3CCCCCC3)=CC=C2OC4=C1C=CC=C4
Biological Activity: H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R . H3R antagonist 2 shows inhibitory effects with IC50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB[1].
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H3R antagonist 2 | H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R . H3R antagonist 2 shows inhibitory effects with IC50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB. | |||||||||||||||||||||
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