1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. AChE
    Beta-secretase
    ROS
  3. AChE/BChE/BACE-1-IN-2

AChE/BChE/BACE-1-IN-2 

Cat. No.: HY-147659
Handling Instructions

AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential.

For research use only. We do not sell to patients.

AChE/BChE/BACE-1-IN-2 Chemical Structure

AChE/BChE/BACE-1-IN-2 Chemical Structure

CAS No. : 1877000-20-8

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Description

AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential[1].

IC50 & Target

IC50: 0.069 μM (hAChE), 0.097 μM (hBACE-1), 0.127 μM (hBChE)[1]

In Vivo

AChE/BChE/BACE-1-IN-2 (Compound 4o) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.36

Formula

C18H20F2N2

CAS No.
SMILES

FC1=CC(F)=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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AChE/BChE/BACE-1-IN-2
Cat. No.:
HY-147659
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