1877000-20-8
Chemical Structure
AChE/BChE/BACE-1-IN-2
- CAS No.: 1877000-20-8
- Formula:C18H20F2N2
- Molecular Weight:302.36
IUPAC Name: 1-benzyl-N-(2,4-difluorobenzyl)pyrrolidin-3-amine
InChIKey: GZGCQOBTRUVMOI-UHFFFAOYSA-N
SMILES: FC1=CC(F)=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3
Biological Activity: AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential[1].
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AChE/BChE/BACE-1-IN-2 | AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential. | |||||||||||||||||||||
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Keywords
