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Cat. No.: HY-161243

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AChE-IN-56

AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₉ClN₄O₅S
Molecular Weight:509.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AChE-IN-56 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy^[1].

IC₅₀ & Target

AChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vivo

AChe-IN-56 (2 mg/kg, p.o., 5 days) exhibits an inhibitory efficacy in scopolamine-induced memory impairment and learning disability in Swiss albino mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

scopolamine-induced memory and learning disability in swiss albino mice ^[1]
Dosage:

2 mg/kg
Administration:

p.o., for 5 days
Result:

Reduced escape latency, restored the levels of AChE, lipids peroxidation, nitrit and oxidative stress and inhibited the production of ROS and RNS.

Chemical Information

Molecular Weight 509.02
Formula C₂₃H₂₉ClN₄O₅S
SMILES

O=S(C1=CC=C(Cl)C=N1)(NC2CCN(C3C(N(CC4=CC=C(OC)C(OC)=C4)CC3)=O)CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gupta M, et al., Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer's agents: synthesis, in-silico and pharmacological evaluations. Sci Rep. 2024 Jan 19;14(1):1687. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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