1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. Epoxide Hydrolase
    Cholinesterase (ChE)
  3. sEH/AChE-IN-3

sEH/AChE-IN-3 

Cat. No.: HY-145833
Handling Instructions

sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively.

For research use only. We do not sell to patients.

sEH/AChE-IN-3 Chemical Structure

sEH/AChE-IN-3 Chemical Structure

CAS No. : 2490589-11-0

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Description

sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1].

IC50 & Target

IC50: 0.4 nM (hsEH), 1.94 ± 0.67 nM (hAChE), 615 ± 34 nM (hBChE), 4.3 nM (msEH), 2.61 ± 0.16 nM (mAChE)[1]

Molecular Weight

670.16

Formula

C35H39ClF3N5O3

CAS No.
SMILES

O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CCCCNC3=C([[email protected]]4([H])CC(C)=C[[email protected]](C4)([H])C5)C5=NC6=CC(Cl)=CC=C36)=O)CC2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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sEH/AChE-IN-3
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