2490589-11-0
Chemical Structure
sEH/AChE-IN-3
- CAS No.: 2490589-11-0
- Formula:C35H39ClF3N5O3
- Molecular Weight:670.16
IUPAC Name: 1-(1-(5-(((7S,11S)-3-chloro-9-methyl-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-12-yl)amino)pentanoyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
InChIKey: VPHLBLQNXMWQOL-XZOQPEGZSA-N
SMILES: O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CCCCNC3=C([C@]4([H])CC(C)=C[C@](C4)([H])C5)C5=NC6=CC(Cl)=CC=C36)=O)CC2
Biological Activity: sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1].
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sEH/AChE-IN-3 | sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively. | |||||||||||||||||||||
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Keywords
