2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Fasciculin-I

Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .

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Fasciculin-I Chemical Structure

Fasciculin-I Chemical Structure

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Fasciculin-I Related Antibodies

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Description

Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes [1].

Molecular Weight

6798.69

Formula

C281H441N87O90S10
Sequence

Thr-Met-Cys-Tyr-Ser-His-Thr-Thr-Thr-Ser-Arg-Ala-Ile-Leu-Thr-Asn-Cys-Gly-Glu-Asn-Ser-Cys-Tyr-Arg-Lys-Ser-Arg-Arg-His-Pro-Pro-Lys-Met-Val-Leu-Gly-Arg-Gly-Cys-Gly-Cys-Pro-Pro-Gly-Asp-Asp-Tyr-Leu-Glu-Val-Lys-Cys-Cys-Thr-Ser-Pro-Asp-Lys-Cys-Asn-Tyr (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52;Cys53-Cys59)
Sequence Shortening

TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDYLEVKCCTSPDKCNY (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52;Cys53-Cys59)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fasciculin-I Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fasciculin-IFAS-ICholinesterase (ChE)acetylcholinesteraseelapid peptidessnake toxinsInhibitorinhibitorinhibit

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