1. Cell Cycle/DNA Damage Neuronal Signaling Anti-infection
  2. G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV
  3. TMPyP4 tosylate

TMPyP4 tosylate  (Synonyms: TMP 1363)

Cat. No.: HY-108477 Purity: ≥98.0%
COA Handling Instructions

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2.

For research use only. We do not sell to patients.

TMPyP4 tosylate Chemical Structure

TMPyP4 tosylate Chemical Structure

CAS No. : 36951-72-1

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Based on 1 publication(s) in Google Scholar

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Description

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2[1][2][3][6].

IC50 & Target[2][3][6]

AChE

 

G-quadruplex

 

Telomerase

 

SARS-CoV-2

 

In Vitro

TMPyP4 tosylate (50  µM, 96 h) inhibits telomerase activity in telomerase positive HOS cells[2].
TMPyP4 tosylate (50  µM, 48 or 96 h) inhibits the growth of HOS cells[2].
TMPyP4 tosylate (50  µM, 96 h) induces cell apoptosis in HOS, Saos-2, MG-63, and U2OS cell lines[2].
TMPyP4 tosylate (100  µM, 24 or 48 h) increases cell cycle regulatory proteins and MAPKs in K562 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HOS cells
Concentration: 50  µM
Incubation Time: 48 or 96 h
Result: Time-dependently inhibited cell viability.

Western Blot Analysis[4]

Cell Line: K562 cells
Concentration: 100  µM
Incubation Time: 24 or 48 h
Result: Increased the expression of p21CIP1 protein and p57KIP2 protein.
In Vivo

TMPyP4 tosylate (10 and 20 mg/kg, i.p., two times weekly) inhibits tumor growth in MX-1 tumor model[5].
TMPyP4 tosylate (15 mg/kg or 30 mg/kg, i.n.) decreases the mean viral loads in SARS-CoV-2-infected hamster[6].
TMPyP4 tosylate (30 mg/kg, i.n., hamsters) shows a Cmax of 17.88 μg/mL at 1 h, and a half-life (T1/2) of 6.36 h[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MX-1 mammary chemoadjuvant model[5]
Dosage: 10 and 20 mg/kg
Administration: Intraperitoneal injection (i.p.), twice weekly.
Result: Inhibited tumor growth and prolonged mice survival.
Animal Model: SARS-CoV-2-infected hamster[6]
Dosage: 15 mg/kg or 30 mg/kg
Administration: i.n., starting at 1 h prior to virus inoculation and continuing until 3 days post infection
Result: Decreased the mean viral loads in the nasal wash, nasal turbinate and lung tissues.
Molecular Weight

1363.60

Formula

C72H66N8O12S4

CAS No.
Appearance

Solid

Color

Pale purple to purple

SMILES

C[N+]1=CC=C(/C2=C3C=CC(/C(C4=CC=[N+](C)C=C4)=C5C=C/C(N/5)=C(C6=CC=[N+](C)C=C6)/C(C=C/7)=NC7=C(C8=CC=[N+](C)C=C8)/C9=CC=C2N9)=N\3)C=C1.O=S(C%10=CC=C(C)C=C%10)([O-])=O.O=S(C%11=CC=C(C)C=C%11)([O-])=O.O=S(C%12=CC=C(C)C=C%12)([O-])=O.O=S(C%13=CC=C(C)C=C%13)([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (7.33 mM; Need ultrasonic)

H2O : 5 mg/mL (3.67 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7334 mL 3.6668 mL 7.3335 mL
5 mM 0.1467 mL 0.7334 mL 1.4667 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 7.14 mg/mL (5.24 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1 mg/mL (0.73 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1 mg/mL (0.73 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TMPyP4 tosylate
Cat. No.:
HY-108477
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