Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug

  • Bioorg Med Chem Lett. 2006 Dec 1;16(23):5982-7. doi: 10.1016/j.bmcl.2006.08.115.
Tomoko Fukuuchi  1 ,  Katsumi Doh-Ura ,  Shin'ichi Yoshihara ,  Shigeru Ohta
Affiliations
  • 1. Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. [email protected]
PMID: 16987659 DOI: 10.1016/j.bmcl.2006.08.115
Abstract

Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of Prion Protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.