2. Cell Cycle/DNA Damage Apoptosis
  3. DNA Alkylator/Crosslinker Photosensitizer
  4. TMPyP tetrachloride

TMPyP tetrachloride is a DNA-binding agent, singlet oxygen Sensitizer and photobleaching agent. TMPyP tetrachloride binds to DNA via intercalation or external groove complexation; irradiation induces its photoinduced release from DNA. TMPyP tetrachloride sensitizes the generation of singlet molecular oxygen upon irradiation, and prolonged irradiation leads to photobleaching. TMPyP tetrachloride initially localizes preferentially in neuronal nuclei and cytoplasm, and irradiation triggers its subcellular relocalization. TMPyP tetrachloride binds to K+ -free single-molecule G4-DNA nanowires via intercalation, and binds to K+ -type variants via non-intercalation. TMPyP tetrachloride can be used in studies related to cancer, HIV infection and bacterial infection.

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TMPyP tetrachloride

TMPyP tetrachloride Chemical Structure

CAS No. : 92739-63-4

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TMPyP tetrachloride Related Antibodies

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Description

TMPyP tetrachloride is a DNA-binding agent, singlet oxygen Sensitizer and photobleaching agent. TMPyP tetrachloride binds to DNA via intercalation or external groove complexation; irradiation induces its photoinduced release from DNA. TMPyP tetrachloride sensitizes the generation of singlet molecular oxygen upon irradiation, and prolonged irradiation leads to photobleaching. TMPyP tetrachloride initially localizes preferentially in neuronal nuclei and cytoplasm, and irradiation triggers its subcellular relocalization. TMPyP tetrachloride binds to K+ -free single-molecule G4-DNA nanowires via intercalation, and binds to K+ -type variants via non-intercalation. TMPyP tetrachloride can be used in studies related to cancer, HIV infection and bacterial infection[1][2][3].

In Vitro

TMPyP (2.5-20 μM; 20 min irradiation) tetrachloride binds to calf thymus DNA, altering its photophysical properties, and irradiation induces photoinduced release of TMPyP from DNA; binding to DNA increases TMPyP's triplet lifetime to 27.8 μs by reducing oxygen quenching[1].
TMPyP (50 μM) tetrachloride acts as a sensitizer to generate detectable singlet oxygen phosphorescence (λmax ~1270 nm) in oxygenated D2O solutions, with the signal completely quenched by 600 μM sodium azide[1].
TMPyP (0.5 TMPyP to G-tetrad molar ratio, 5-8 μM; 30 min-1 h) tetrachloride binds with high affinity via an intercalative mechanism to monomolecular K+-free G4-DNA nanowires, forming a stable complex with a 0.5 TMPyP to G-tetrad molar ratio, characterized by a 19 nm Soret band red shift, 58% hypochromicity, negative induced CD, and efficient energy transfer[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TMPyP tetrachloride Related Antibodies
Molecular Weight

820.64

Formula

C44H38Cl4N8
CAS No.
Appearance

Solid

Color

Dark purple to black

SMILES

C[N+](C=C1)=CC=C1/C(C2=CC=C(/C(C3=CC=[N+](C)C=C3)=C4N=C(/C(C5=CC=[N+](C)C=C5)=C6C=C/C(N/6)=C7\C8=CC=[N+](C)C=C8)C=C\4)N2)=C9C=CC7=N\9.[4Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (60.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2186 mL 6.0928 mL 12.1856 mL
5 mM 0.2437 mL 1.2186 mL 2.4371 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2186 mL 6.0928 mL 12.1856 mL 30.4640 mL
5 mM 0.2437 mL 1.2186 mL 2.4371 mL 6.0928 mL
10 mM 0.1219 mL 0.6093 mL 1.2186 mL 3.0464 mL
15 mM 0.0812 mL 0.4062 mL 0.8124 mL 2.0309 mL
20 mM 0.0609 mL 0.3046 mL 0.6093 mL 1.5232 mL
25 mM 0.0487 mL 0.2437 mL 0.4874 mL 1.2186 mL
30 mM 0.0406 mL 0.2031 mL 0.4062 mL 1.0155 mL
40 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7616 mL
50 mM 0.0244 mL 0.1219 mL 0.2437 mL 0.6093 mL
60 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.5077 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TMPyP tetrachloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMPyP tetrachloride92739-63-4DNA Alkylator/CrosslinkerPhotosensitizerG4-DNA nanowiresHIV infectionsinglet oxygenbacterial infectionsDNAneuronal cytoplasmneuronal nucleicancertelomeric oligonucleotidesG-quadruplex structuresInhibitorinhibitorinhibit

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