1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. MMP
    AChE
  3. Polygalacic acid

Polygalacic acid 

Cat. No.: HY-N0801
Handling Instructions

Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.

For research use only. We do not sell to patients.

Polygalacic acid Chemical Structure

Polygalacic acid Chemical Structure

CAS No. : 22338-71-2

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Description

Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].

In Vitro

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1].
Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1].

RT-PCR[1]

Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time: 24 hours
Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Western Blot Analysis[1]

Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time: 6 hours
Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.
Molecular Weight

504.70

Formula

C₃₀H₄₈O₆

CAS No.

22338-71-2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Polygalacic acidMMPAChEMatrix metalloproteinasesAcetylcholinesteraseInhibitorinhibitorinhibit

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Polygalacic acid
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HY-N0801
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