22338-71-2
Chemical Structure
Polygalacic acid
- CAS No.: 22338-71-2
- Formula:C30H48O6
- Molecular Weight:504.70
IUPAC Name: (4aR,5R,6aS,6bR,8aR,9R,10R,11S,12aR,12bR,14bS)-5,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
InChIKey: KGGGRGBDMBZXKF-PWFIOIGMSA-N
SMILES: C[C@]([C@@]1([H])[C@]2(C[C@H](O)[C@@H]3O)C)(CC[C@@]2([H])[C@]3(C)CO)[C@@](C4=CC1)(C[C@@H](O)[C@]5(C(O)=O)[C@@]4([H])CC(C)(C)CC5)C
Biological Activity: Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Polygalacic acid | 98.92% | Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex. | ||||||||||||||||||||
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Similarity Score 0.89
HY-N1991Platicodigenin -
Similarity Score 0.87
HY-N7687Caulophyllogenin -
Similarity Score 0.84
HY-N1719Isoarjunolic acid -
Similarity Score 0.84
HY-N17202α,3α,24-Trihydroxyolean-12-en-28-oic acid -
Similarity Score 0.84
HY-N1932Bayogenin -
Similarity Score 0.84
HY-N2896Arjunolic acid -
Similarity Score 0.81
HY-N0839Quillaic acid -
Similarity Score 0.81
HY-N0271Echinocystic acid -
Similarity Score 0.81
HY-N13031Bellericagenin A -
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References
- [1]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23(2):149-55. [Content Brief]
- [2]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252. [Content Brief]
