Kokusaginine
Based on 1 Customer Validation
Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 484-08-2
- Formula: C14H13NO4
- Molecular Weight:259.26
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE 28.2 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
3.5 μg/mL
Compound: 5
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Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
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[PMID: 12713408] |
| BMDM | IC50 |
3.16 μM
Compound: AC-542/20643020
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Inhibition of GST-tagged recombinant RANKL/M-CSF-induced osteoclastogenesis in C57BL/6 mouse bone marrow derived macrophages assessed as TRAcP enzymatic activity incubated for 5 days with subsequent replenishment of media for 2 days and measured by leucoc
Inhibition of GST-tagged recombinant RANKL/M-CSF-induced osteoclastogenesis in C57BL/6 mouse bone marrow derived macrophages assessed as TRAcP enzymatic activity incubated for 5 days with subsequent replenishment of media for 2 days and measured by leucoc
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[PMID: 33158578] |
| MCF7 | IC50 |
7.23 μM
Compound: Kokusaginine
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Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
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[PMID: 29903663] |
| MDA-MB-231 | IC50 |
9.01 μM
Compound: Kokusaginine
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Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
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[PMID: 29903663] |
| N1E-115 | IC50 |
200 μM
Compound: 1a
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Inhibition of N1E-115 cells Kv channels
Inhibition of N1E-115 cells Kv channels
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[PMID: 11312924] |
| NCI/ADR-RES | IC50 |
4.62 μM
Compound: Kokusaginine
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Growth inhibition of human MCF7/ADR cells after 48 hrs by MTT assay
Growth inhibition of human MCF7/ADR cells after 48 hrs by MTT assay
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[PMID: 29903663] |
| Neutrophil | IC50 |
61.8 μM
Compound: 10
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Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of luminol-induced oxidative burst by chemiluminescence assay
Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of luminol-induced oxidative burst by chemiluminescence assay
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[PMID: 18950230] |
Kokusaginine (0-30 μM) inhibits proliferations of cells MCF-7, MDA-MB-231 and their multidrug resistant sublines MCF-7/ADR, MDA-MB-231/ADR, with IC50s of 7.23, 4.62, 9.01 and 10.19 μM through inhibition of tubulin polymerization[2].
Kokusaginine (6-24 μM) induces apoptosis in cells MCF-7 and MCF-7/ADR in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 484-08-2
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Appearance Solid
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Molecular Weight 259.26
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Formula C14H13NO4
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Color White to off-white
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SMILES
COC1=C(C=C2C(OC)=C3C(OC=C3)=NC2=C1)OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sichaem J, et al., Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015 Aug;10(8):1359-62. [Content Brief]
[2]. Chen H, et al., The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2490-2492. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kokusaginine Related Classifications
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