1. Neuronal Signaling
  2. AChE
  3. Physostigmine salicylate

Physostigmine salicylate (Synonyms: Eserine salicylate)

Cat. No.: HY-B1266 Purity: ≥99.00%
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Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning.

For research use only. We do not sell to patients.

Physostigmine salicylate Chemical Structure

Physostigmine salicylate Chemical Structure

CAS No. : 57-64-7

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5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
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25 mg USD 140 In-stock
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50 mg USD 210 In-stock
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100 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4].

In Vivo

Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2].
Physostigmine salicylate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Heterozygous transgenic mice (Tg(+) mice)[2]
Dosage: 0.03, 0.1, and 0.3 mg/kg
Administration: SC; daily for 6 weeks
Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
Clinical Trial
Molecular Weight

413.47

Formula

C₂₂H₂₇N₃O₅

CAS No.
SMILES

O=C(O)C1=CC=CC=C1O.O=C(OC2=CC3=C(N(C)[[email protected]]4([H])[[email protected]@]3(C)CCN4C)C=C2)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (604.64 mM; Need ultrasonic)

H2O : 33.33 mg/mL (80.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4186 mL 12.0928 mL 24.1856 mL
5 mM 0.4837 mL 2.4186 mL 4.8371 mL
10 mM 0.2419 mL 1.2093 mL 2.4186 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PhysostigmineEserineAChEAcetylcholinesteraseblood-brainbarrierAlzheimer'santidoteInhibitorinhibitorinhibit

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Product Name:
Physostigmine salicylate
Cat. No.:
HY-B1266
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