1. Neuronal Signaling
  2. AChE
  3. Physostigmine

Physostigmine (Synonyms: Eserine)

Cat. No.: HY-N6608
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Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and elevate acetylcholine levels in the brain. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.

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Physostigmine Chemical Structure

Physostigmine Chemical Structure

CAS No. : 57-47-6

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Description

Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and elevate acetylcholine levels in the brain. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3].

In Vivo

Physostigmine (Eserine) (0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2].

Animal Model: Heterozygous transgenic mice (Tg(+) mice)[2]
Dosage: 0.03, 0.1, and 0.3 mg/kg
Administration: S.c.; daily for 6 weeks
Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
Molecular Weight

275.35

Formula

C₁₅H₂₁N₃O₂

CAS No.

57-47-6

SMILES

CN1[[email protected]](N(C)CC2)([H])[[email protected]]2(C)C3=C1C=CC(OC(NC)=O)=C3

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Keywords:

PhysostigmineEserineAChEAcetylcholinesteraseblood-brainbarriermemorytransgenicmiceanticholinergicpoisoningantidoteInhibitorinhibitorinhibit

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