Annonaceae

N-TRANS-CaffeoyLtyramine is an effective inflammatory response regulator, which has antioxidant activity and anticoagulation effects.

Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.

Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.

Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO^- and SIN-1-derived ONOO^- with IC₅₀s of 3.5 and 9.6 μM, respectively.

Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways.

Oliveroline is an aporphine alkaloid with anticancer activity and a G₂ DNA damage checkpoint inhibitor. Oliveroline enables cells to escape G₂ phase arrest after DNA damage. Oliveroline can be used in research related to various cancers including non-small cell lung cancer, lung cancer, and fibrosarcoma.

Dicentrinone is an orally active PDI inhibitor with an IC₅₀ value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis.

Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

(-)-Syringaresinol is an orally active isomer of syringaresinol (HY-N8307) found in Annona Montana. (-)-Syringaresinol exhibits antioxidant, anti-inflammatory, and anticancer activities. (-)-Syringaresinol can alleviate ulcerative colitis via the PI3K-Akt/MAPK/Wnt signaling pathway. (-)-Syringaresinol inhibits HL-60 cell proliferation by arresting the G1 phase and inducing apoptosis. (-)-Syringaresinol inhibits LPS (HY-D1056)-induced microglial activation by downregulating the NF-κB p65 signaling pathway and its interaction with ERβ, exerting anti-neuroinflammatory effects.

Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor.

Isoeugenol acetate (Acetyl isoeugenol) is a derivative of Isoeugenol (HY-N1952). Isoeugenol acetate is an inhibitor for ferroptosis.

Lysicamine, a natural compound, possesses antibacterial, anticancer and anti-inflammation activity.

(-)-Zeylenol, isaolated from stems of Uvaria grandiflora, possesses anti-inflammatory and anticancer activities.

N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC₅₀ of 103.58 μM).

Goniotriol(compound 2) is a styrylpyronethat can be found in Goniothalamus amuyon. Goniotriolshows cytotoxicity.

Schizandriside is a cerebroside, which can be isolated from Uvaria tonkinensis var..

3-Methoxyflavone is a flavonoid compound isolated from Artemisia incanescens with antiviral activity.

Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC₅₀ value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis .

Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways.