62560-99-0
62560-99-0
Chemical Structure
Oliveroline
- CAS No.: 62560-99-0
- Formula:C18H17NO3
- Molecular Weight:295.33
InChIKey: NVMGTUCOAQKLLO-IRXDYDNUSA-N
SMILES: O[C@@H]1[C@]2([H])C3=C(CCN2C)C=C(OCO4)C4=C3C5=CC=CC=C51
Biological Activity: Oliveroline is an aporphine alkaloid with anticancer activity and a G2 DNA damage checkpoint inhibitor. Oliveroline enables cells to escape G2 phase arrest after DNA damage. Oliveroline can be used in research related to various cancers including non-small cell lung cancer, lung cancer, and fibrosarcoma[1][2].
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Oliveroline | Oliveroline is an aporphine alkaloid with anticancer activity and a G2 DNA damage checkpoint inhibitor. Oliveroline enables cells to escape G2 phase arrest after DNA damage. Oliveroline can be used in research related to various cancers including non-small cell lung cancer, lung cancer, and fibrosarcoma. | |||||||||||||||||||||
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References
- [1]. Brastianos HC, et al. Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata. Journal of natural products. 2007 Feb;70(2):287-8. [Content Brief]
- [2]. Chan YY, et al. The constituents of Michelia compressa var. formosana and their bioactivities. International journal of molecular sciences. 2014 Jun 17;15(6):10926-35. [Content Brief]
