Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata

  • J Nat Prod. 2007 Feb;70(2):287-8. doi: 10.1021/np060285e.
Harry C Brastianos  1 ,  Christopher M Sturgeon ,  Michel Roberge ,  Raymond J Andersen
Affiliations
  • 1. Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
PMID: 17315964 DOI: 10.1021/np060285e
Abstract

Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G2 DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G2 checkpoint inhibitory activity of the D. odorata extract. The new alkaloid N-methylguatterine (2) was identified during this investigation.

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