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  6. Oliveroline

Oliveroline is an aporphine alkaloid with anticancer activity and a G2 DNA damage checkpoint inhibitor. Oliveroline enables cells to escape G2 phase arrest after DNA damage. Oliveroline can be used in research related to various cancers including non-small cell lung cancer, lung cancer, and fibrosarcoma.

For research use only. We do not sell to patients.

Oliveroline

Oliveroline Chemical Structure

CAS No. : 62560-99-0

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Oliveroline Related Antibodies

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Description

Oliveroline is an aporphine alkaloid with anticancer activity and a G2 DNA damage checkpoint inhibitor. Oliveroline enables cells to escape G2 phase arrest after DNA damage. Oliveroline can be used in research related to various cancers including non-small cell lung cancer, lung cancer, and fibrosarcoma[1][2].

In Vitro

Oliveroline (compound 1) (0.01-100 μM; 8 h post-irradiation) inhibits the G2 DNA damage checkpoint in MCF-7 mp53 cells in a concentration-dependent manner[1].
Oliveroline (24 h pre-irradiation) inhibits proliferation of MCF-7 mp53 cells with an IC50 of 45 μM in the absence of DNA damage, and shows ~2.3-fold increased potency (IC50 = 20 μM) in cells treated with 6.5 Gy ionizing radiation[1].
Oliveroline inhibits the growth of human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549), and fibrosarcoma (HT1080) cell lines, with the highest potency against A498 cells (IC50 = 3.68 μM) and IC50 values ranging from 3.68-13.28 μM across all lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oliveroline Related Antibodies
Molecular Weight

295.33

Formula

C18H17NO3
CAS No.
SMILES

O[C@@H]1[C@]2([H])C3=C(CCN2C)C=C(OCO4)C4=C3C5=CC=CC=C51
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Oliveroline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oliveroline62560-99-0Otherslung carcinomaChk1 kinasehuman nasopharyngeal carcinomanon-small cell lung carcinomarenal carcinomaG2 DNA damage checkpointDuguetia odorataT cell leukemiaMichelia compressa var. formosanafibrosarcomaInhibitorinhibitorinhibit

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