The constituents of Michelia compressa var. formosana and their bioactivities

  • Int J Mol Sci. 2014 Jun 17;15(6):10926-35. doi: 10.3390/ijms150610926.
Yu-Yi Chan  1 ,  Shin-Hun Juang  2 ,  Guan-Jhong Huang  3 ,  Yu-Ren Liao  4 ,  Yu-Fon Chen  5 ,  Chia-Che Wu  6 ,  Hui-Ting Chang  7 ,  Tian-Shung Wu  8
Affiliations
  • 1. Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. [email protected].
  • 2. Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan. [email protected].
  • 3. Department of Pharmacy, China Medical University, Taichung 40402, Taiwan. [email protected].
  • 4. Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. [email protected].
  • 5. Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan. [email protected].
  • 6. School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. [email protected].
  • 7. School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. [email protected].
  • 8. Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. [email protected].
PMID: 24941253 DOI: 10.3390/ijms150610926
Abstract

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and Anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5±0.3 and 9.6±0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.

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