3696-28-4
3696-28-4
Chemical Structure
Dipyrithione
- CAS No.: 3696-28-4
- Formula:C10H8N2O2S2
- Molecular Weight:252.31
IUPAC Name: 2,2'-disulfanediylbis(pyridine 1-oxide)
InChIKey: ZHDBTKPXEJDTTQ-UHFFFAOYSA-N
SMILES: [O-][N+]1=CC=CC=C1SSC2=CC=CC=[N+]2[O-]
Biological Activity: Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dipyrithione | 99.92% | Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis. | ||||||||||||||||||||
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Dipyrithione (Standard) | ≥98% | Dipyrithione (Standard) is the analytical standard of Dipyrithione (HY-N8432). This product is intended for research and analytical applications. Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.61
HY-147887Tubulin inhibitor 28 -
Similarity Score 0.58
HY-W104758LasR antagonist-2 -
Similarity Score 0.57
HY-W8560041,2-Bis(2-fluoropyridin-4-yl)disulfane -
Similarity Score 0.56
![1,1'-Dimethyl-[4,4'-bipyridine]-1,1'-diiumiodide Chemical Structure](//file.medchemexpress.com/product_pic/hy-w112143.gif)
HY-W1121431,1'-Dimethyl-[4,4'-bipyridine]-1,1'-diiumiodide -
Similarity Score 0.56
HY-W0092133-Nitrophenyl disulfide -
Similarity Score 0.56
![1,1'-Diethyl-[4,4'-bipyridine]-1,1'-diium bromide Chemical Structure](//file.medchemexpress.com/product_pic/hy-w011069.gif)
HY-W0110691,1'-Diethyl-[4,4'-bipyridine]-1,1'-diium bromide -
Similarity Score 0.56
HY-W2489931,2-Bis(pyridin-4-ylthio)ethane -
Similarity Score 0.55
HY-W0314233,3'-Disulfanediyldibenzoic acid -
Similarity Score 0.55
HY-W112332A(1E,2E)-1,2-Bis(pyridin-4-ylmethylene)hydrazine -
Explore the MedChemAI to find more analogs
![1,1'-Dimethyl-[4,4'-bipyridine]-1,1'-diiumiodide Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w112143.gif)
![1,1'-Diethyl-[4,4'-bipyridine]-1,1'-diium bromide Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w011069.gif)
References
- [1]. Song X, et al. In vivo antifungal activity of dipyrithione against Trichophyton rubrum on guinea pig dermatophytosis models. Biomed Pharmacother. 2018 Dec;108:558-564. [Content Brief]
- [2]. Liu Z, et al. Dipyrithione inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice. FEBS Lett. 2008 May 28;582(12):1643-50. [Content Brief]
- [3]. Fan Y, et al. Dipyrithione induces cell-cycle arrest and apoptosis in four cancer cell lines in vitro and inhibits tumor growth in a mouse model. BMC Pharmacol Toxicol. 2013 Oct 21;14:54. [Content Brief]
