1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Podocarpic acid

Podocarpic acid 

Cat. No.: HY-N2318 Purity: 99.56%
Handling Instructions

Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

For research use only. We do not sell to patients.

Podocarpic acid Chemical Structure

Podocarpic acid Chemical Structure

CAS No. : 5947-49-9

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10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

In Vitro

Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells[2].

In Vivo

Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca2+ flux, which is significantly reduces when the Ca2+-impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels[1].

Molecular Weight

274.35

Formula

C₁₇H₂₂O₃

CAS No.

5947-49-9

SMILES

O=C([[email protected]@]1(C)CCC[[email protected]]2(C)C3=C(CC[[email protected]@]12[H])C=CC(O)=C3)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (364.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6450 mL 18.2249 mL 36.4498 mL
5 mM 0.7290 mL 3.6450 mL 7.2900 mL
10 mM 0.3645 mL 1.8225 mL 3.6450 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.56%

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Keywords:

Podocarpic acidTRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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Podocarpic acid
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