Cat. No.: HY-N8307

Syringaresinol

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Based on 1 Customer Validation

Syringaresinol is a lignan-type phytochemical with anti-inflammatory activities. Syringaresinol inhibits the NF-κB and AKT signaling pathway in IL-1β-activated mouse chondrocytes. Syringaresinol increases phosphorylation of AMPK, eNOS, and intracellular Ca²⁺ levels in HUVECs. Syringaresinol attenuates osteoarthritis progression in mice with Destabilization of the Medial Meniscus (DMM)-induced osteoarthritis. Syringaresinol can be used for the study of osteoarthritis (OA).

For research use only. We do not sell to patients.

Purity: 99.66%
CAS No.: 487-35-4
Formula: C₂₂H₂₆O₈
Molecular Weight:418.44

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Syringaresinol Chemical Structure

CAS No.: 487-35-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NO Synthase Isoforms :

All NF-κB Isoforms :

All Akt Isoforms :

All AMPK Isoforms :

All Calcium Channel Isoforms :

In Vitro

Syringaresinol (0-100 μM, 2 h pretreatment) dose-dependently decreases the production of inflammatory mediators (PGE2, IL-6, TNF-α, NO) and downregulates the protein expression of iNOS and COX-2 in IL-1β-activated mouse chondrocytes^[1].
Syringaresinol (0-100 μM, 2 h pretreatment) upregulates the production of ECM components and downregulates the secretion of ECM-degrading enzymes in IL-1β-activated mouse chondrocytes^[1].
Syringaresinol (0-100 μM, 2 h pretreatment) inhibits the activation of the NF-κB and AKT signaling pathway^[1].
Syringaresinol (10-30 μM, 30 min) dose-dependently increases phosphorylation of Akt, AMPK, and eNOS, and increases intracellular Ca²⁺ levels in HUVECs^[2].
Syringaresinol (30 μM, 30 min) significantly increases eNOS dimerization and decreases eNOS monomer in HUVECs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

IL-1β-activated mouse chondrocytes
Concentration:

0, 25, 50, 100 μM
Incubation Time:

2 h pretreatment
Result:

Reduced the the production of inflammatory mediators (PGE2, IL-6, TNF-α).
Upregulated the production of ECM components (collagen II, aggrecan).
Downregulated the secretion of ECM-degrading enzymes (MMP-13, ADAMTS-5).

Western Blot Analysis^[1]

Cell Line:

IL-1β-activated mouse chondrocytes
Concentration:

0, 25, 50, 100 μM
Incubation Time:

2 h pretreatment
Result:

Downregulated the protein expression of iNOS and COX-2.
Suppressed IL-1β-induced degradation of IκB-α, phosphorylation of p65, and nuclear translocation of p65.
Decreased IL-1β-induced phosphorylation of AKT.

In Vivo

Syringaresinol (10 mg/kg, intra-articular injection, once weekly for 4 consecutive weeks) attenuates osteoarthritis progression in mice with DMM-induced osteoarthritis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

60-day-old male C57BL/6 mice with DMM-induced osteoarthritis^[1]
Dosage:

10 mg/kg
Administration:

Intra-articular injection, once weekly for 4 consecutive weeks
Result:

Reduced joint space narrowing, osteophyte formation and cartilage calcification (X-ray detection).
Alleviated cartilage erosion and proteoglycan depletion.
Reversed the elevation of Osteoarthritis Research Society International (OARSI) scores.
Decreased COX-2 protein expression in cartilage tissue.

Chemical Information

CAS No. 487-35-4
Appearance Solid
Molecular Weight 418.44
Formula C₂₂H₂₆O₈
Color White to off-white
SMILES

OC1=C(OC)C=C(C2OCC3C2COC3C4=CC(OC)=C(O)C(OC)=C4)C=C1OC
Structure Classification
- Phenylpropanoids
- Lignans
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (119.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3898 mL

11.9491 mL

23.8983 mL

5 mM

0.4780 mL

2.3898 mL

4.7797 mL

10 mM

0.2390 mL

1.1949 mL

2.3898 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023 May;118:109982. [Content Brief]

[2]. Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44(3):191-201. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3898 mL	11.9491 mL	23.8983 mL	59.7457 mL
	5 mM	0.4780 mL	2.3898 mL	4.7797 mL	11.9491 mL
	10 mM	0.2390 mL	1.1949 mL	2.3898 mL	5.9746 mL
	15 mM	0.1593 mL	0.7966 mL	1.5932 mL	3.9830 mL
	20 mM	0.1195 mL	0.5975 mL	1.1949 mL	2.9873 mL
	25 mM	0.0956 mL	0.4780 mL	0.9559 mL	2.3898 mL
	30 mM	0.0797 mL	0.3983 mL	0.7966 mL	1.9915 mL
	40 mM	0.0597 mL	0.2987 mL	0.5975 mL	1.4936 mL
	50 mM	0.0478 mL	0.2390 mL	0.4780 mL	1.1949 mL
	60 mM	0.0398 mL	0.1992 mL	0.3983 mL	0.9958 mL
	80 mM	0.0299 mL	0.1494 mL	0.2987 mL	0.7468 mL
	100 mM	0.0239 mL	0.1195 mL	0.2390 mL	0.5975 mL

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Syringaresinol

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All NO Synthase Isoforms

All NF-κB Isoforms