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Cat. No.: HY-N20649

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Isorhamnetin-3-O-rhamnoside

Isorhamnetin-3-O-rhamnoside is an acetylcholinesterase (AChE) inhibitor with moderate antioxidant activity, with an IC₅₀ of 73.96 µM against electric eel AChE. Isorhamnetin-3-O-rhamnoside significantly inhibits the proliferation of mammary adenocarcinoma cells, but exerts relatively weak inhibitory effects on liver cancer cells and lung cancer cells. Isorhamnetin-3-O-rhamnoside can be widely used in studies related to Alzheimer's disease and human mammary adenocarcinoma.

For research use only. We do not sell to patients.

CAS No.: 67068-82-0
Formula: C₂₂H₂₂O₁₁
Molecular Weight:462.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Isorhamnetin-3-O-rhamnoside Chemical Structure

CAS No.: 67068-82-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

electric eel AChE

73.96 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

Isorhamnetin-3-O-rhamnoside (40-160 μM; 72 h) exhibits low cytotoxicity against HepG2 and A549 cells, and strong cytotoxicity with a 51% proliferation inhibition rate against MCF-7 cells at 160 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

human hepatoma HepG2 cells, human breast adenocarcinoma MCF-7 cells, human lung cancer A549 cells
Concentration:

40 μM; 80 μM; 160 μM
Incubation Time:

72 h
Result:

Showed low proliferation inhibition rates in HepG2, MCF-7, and A549 cells at 40 μM.
Showed low proliferation inhibition rates in HepG2 and A549 cells, and a moderate inhibition rate in MCF-7 cells at 80 μM.
Showed low proliferation inhibition rates in HepG2 and A549 cells, and a strong 51% proliferation inhibition rate in MCF-7 cells at 160 μM.

Chemical Information

CAS No. 67068-82-0
Molecular Weight 462.40
Formula C₂₂H₂₂O₁₁
SMILES

O=C(C(O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)=C(C2=CC(OC)=C(C=C2)O)OC3=CC(O)=C4)C3=C4O
Structure Classification
- Flavonoids
- Flavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Olennikov DN, et al.. Isorhamnetin and Quercetin Derivatives as Anti-Acetylcholinesterase Principles of Marigold (Calendula officinalis) Flowers and Preparations. International journal of molecular sciences. 2017 Aug 02;18(8):1685. [Content Brief]

[2]. Chen A, et al.. Synthesis of Isorhamnetin-3--Rhamnoside by a Three-Enzyme (Rhamnosyltransferase, Glycine Max Sucrose Synthase, UDP-Rhamnose Synthase) Cascade Using a UDP-Rhamnose Regeneration System. Molecules (Basel, Switzerland). 2019 Aug 22;24(17):3042.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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