67068-82-0
Chemical Structure
Isorhamnetin-3-O-rhamnoside
- CAS. Nr.: 67068-82-0
- Formula:C22H22O11
- Molecular Weight:462.40
InChIKey: UXXAEVMOIUAYQT-UFGFRKJLSA-N
SMILES: O=C(C(O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)=C(C2=CC(OC)=C(C=C2)O)OC3=CC(O)=C4)C3=C4O
Biological Activity: Isorhamnetin-3-O-rhamnoside is an acetylcholinesterase (AChE) inhibitor with moderate antioxidant activity, with an IC50 of 73.96 µM against electric eel AChE. Isorhamnetin-3-O-rhamnoside significantly inhibits the proliferation of mammary adenocarcinoma cells, but exerts relatively weak inhibitory effects on liver cancer cells and lung cancer cells. Isorhamnetin-3-O-rhamnoside can be widely used in studies related to Alzheimer's disease and human mammary adenocarcinoma[1][2].
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Isorhamnetin-3-O-rhamnoside | Isorhamnetin-3-O-rhamnoside is an acetylcholinesterase (AChE) inhibitor with moderate antioxidant activity, with an IC50 of 73.96 µM against electric eel AChE. Isorhamnetin-3-O-rhamnoside significantly inhibits the proliferation of mammary adenocarcinoma cells, but exerts relatively weak inhibitory effects on liver cancer cells and lung cancer cells. Isorhamnetin-3-O-rhamnoside can be widely used in studies related to Alzheimer's disease and human mammary adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Olennikov DN, et al.. Isorhamnetin and Quercetin Derivatives as Anti-Acetylcholinesterase Principles of Marigold (Calendula officinalis) Flowers and Preparations. International journal of molecular sciences. 2017 Aug 02;18(8):1685. [Content Brief]
- [2]. Chen A, et al.. Synthesis of Isorhamnetin-3--Rhamnoside by a Three-Enzyme (Rhamnosyltransferase, Glycine Max Sucrose Synthase, UDP-Rhamnose Synthase) Cascade Using a UDP-Rhamnose Regeneration System. Molecules (Basel, Switzerland). 2019 Aug 22;24(17):3042.
