2. Anti-infection Metabolic Enzyme/Protease GPCR/G Protein
  3. Parasite Endogenous Metabolite Angiotensin Receptor Bacterial Fungal
  4. Benzyl benzoate

Benzyl benzoate  (Synonyms: Phenylmethyl benzoate)

Cat. No.: HY-B0935 Purity: ≥98.0%
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Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.

For research use only. We do not sell to patients.

Benzyl benzoate Chemical Structure

Benzyl benzoate Chemical Structure

CAS No. : 120-51-4

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Liquid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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5 g USD 60 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Benzyl benzoate:

Benzyl benzoate Related Antibodies

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1 Publications Citing Use of MCE Benzyl benzoate

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry[1][2][3][4][5].

IC50 & Target

Mite

 

In Vitro

Benzyl benzoate (10000-50000 mg/L; 72 h) has toxic effects in allium root cells[3].
Benzyl benzoate (10-100 μM; 1-200 s) inhibits Ang II activity in a dose-dependent manner in 293T cells of human embryonic kidney epithelium (mAT1a(HA)/293T) (IC50=107 μg/mL) without cytotoxicity[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benzyl benzoate Related Antibodies
In Vivo

Benzyl benzoate (25-100 mg/kg; p.o.; Once daily for 90 days) has no significant effects on body weight, relative organ weight, hematology, and biochemical outcomes in rats, but causes pathological changes in liver, kidney, thymus, prostate, and epididymal tissues in Sprague Dawley rats[4].
Benzyl benzoate (2-10 mg/kg; p.o.; Single dose) significantly inhibits Ang II (100 μg/kg) -induced hypertension in Std:ddY mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypertensive male Std:ddY mice model[5]
Dosage: 2 mg/kg, 10 mg/kg
Administration: Oral gavage (p.o.); Single dose. Before Ang II treatment (100 μg/kg; Intraperitoneal injection (i.p.); Single dose)
Result: Significantly inhibited the rise in systolic blood pressure induced by Ang II treatment.
Animal Model: Sprague Dawley male rats model[4]
Dosage: 25 mg/kg, 100 mg/kg
Administration: Oral gavage (p.o.); Once daily for 90 days
Result: Induced hepatic portal vein blood supply, sinusoid sinus enlargement, monocyte infiltration, local lysis and cytoplasmic degeneration in rats.
Induced renal tissue congestion, renal tubule degeneration, monocyte infiltration and histolysis in rats. Resulted in increased number of Hassall’s bodies, elevated lipids, degeneration, congestion, fibrosis and lymphocytopenia in the thymus of rats.
Resulted in vacuolation and irregular secretion of the prostate in male reproductive system tissue, increased connective tissue of the epididymis and presence of cells in the lumen.
In the male reproductive system tissues, resulted in vacuolation and irregular secretion in the prostate, increased connective tissue of the epididymis, and presence of cells in the lumen.
Clinical Trial
Molecular Weight

212.24

Formula

C14H12O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OCC1=CC=CC=C1)C2=CC=CC=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (235.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7116 mL 23.5582 mL 47.1165 mL
5 mM 0.9423 mL 4.7116 mL 9.4233 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7116 mL 23.5582 mL 47.1165 mL 117.7912 mL
5 mM 0.9423 mL 4.7116 mL 9.4233 mL 23.5582 mL
10 mM 0.4712 mL 2.3558 mL 4.7116 mL 11.7791 mL
15 mM 0.3141 mL 1.5705 mL 3.1411 mL 7.8527 mL
20 mM 0.2356 mL 1.1779 mL 2.3558 mL 5.8896 mL
25 mM 0.1885 mL 0.9423 mL 1.8847 mL 4.7116 mL
30 mM 0.1571 mL 0.7853 mL 1.5705 mL 3.9264 mL
40 mM 0.1178 mL 0.5890 mL 1.1779 mL 2.9448 mL
50 mM 0.0942 mL 0.4712 mL 0.9423 mL 2.3558 mL
60 mM 0.0785 mL 0.3926 mL 0.7853 mL 1.9632 mL
80 mM 0.0589 mL 0.2945 mL 0.5890 mL 1.4724 mL
100 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1779 mL
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Benzyl benzoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzyl120-51-4PhenylmethylParasiteEndogenous MetaboliteAngiotensin ReceptorBacterialFungalScabiesacaricidetoxicityhigh blood pressureAng IImAT1a(HA)/293TInhibitorinhibitorinhibit

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