1. Neuronal Signaling
  2. AChE
  3. RX 67668

RX 67668 

Cat. No.: HY-124047
Handling Instructions

RX 67668 is a potent cholinesterase inhibitor with an IC50 of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue.

For research use only. We do not sell to patients.

RX 67668 Chemical Structure

RX 67668 Chemical Structure

CAS No. : 40709-76-0

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Description

RX 67668 is a potent cholinesterase inhibitor with an IC50 of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue[1][2].

IC50 & Target

IC50: 5 μM (acetylcholinesterase) and 5 μM (butyrylcholinesterase)[1]

In Vivo

RX 67668 (1-4 mg/kg; i.p.) reduces by half the dose of methacholine necessary to produce red tears, whilst RX 67668 (7-2 mg/kg s.c.) is necessary to reduce the pupil diameter of the mouse to 50% of the control value[1].
Rat anterior tibialis preparation of the cat tibialis preparation demonstrates that RX 67668 (0.3-1.0 mg/kg; i.v.) is effective in reversing tubocurarine-induced muscle blockade[1].

Molecular Weight

265.82

Formula

C₁₆H₂₄ClN

CAS No.

40709-76-0

SMILES

[H]Cl.N1([[email protected]]2[[email protected]@H](C3=CC=CC=C3)CCCC2)CCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

RX 67668RX67668RX-67668AChEAcetylcholinesterasecholinesteraseacetylcholinesterasebutyrylcholinesteraseneuromuscularblockadeD-tubocurarinemusclerelaxantskeletal fatigueInhibitorinhibitorinhibit

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RX 67668
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