AChE/BChE-IN-1
AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, with IC50s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2720624-42-8
- Formula: C32H35ClN6O3
- Molecular Weight:587.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE |
BChE |
AChE/BChE-IN-1 (compound 5i) is notactive against hBACE-1 at the tested concentration (1 μM)[1].
AChE/BChE-IN-1 scavenges the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, with an IC50 of 92.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AβPPswe/PS-1 double transgenic male mice (10 months)[1]
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Dosage:2 mg/kg
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Administration:I.p. 3 times per week for 4 weeks
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Result:Significantly enhanced learning and memory.
Reduced Aβ42/Aβ40 ratio in the hippocampus.
Increased the strength of synaptic transmission, without affecting long-term potentiation (LTP).
Decreased the levels of oxidative stress and neuroinflammation markers in the hippocampus.
Chemical Information
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CAS No. 2720624-42-8
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Molecular Weight 587.11
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Formula C32H35ClN6O3
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SMILES
O=C(NCC1=CC=C(O)C(OC)=C1)CC2=CN(CCCCC3=CC(C4)CC5=NC6=CC(Cl)=CC=C6C(N)=C5C4C3)N=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BChE-IN-1 Related Classifications
HY-131971 Related Classifications
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