2720624-42-8
Chemical Structure
AChE/BChE-IN-1
- CAS No.: 2720624-42-8
- Formula:C32H35ClN6O3
- Molecular Weight:587.11
IUPAC Name: 2-(1-(4-(12-amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl)-1H-1,2,3-triazol-4-yl)-N-(4-hydroxy-3-methoxybenzyl)acetamide
InChIKey: WMCRFEREEQOYQN-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(O)C(OC)=C1)CC2=CN(CCCCC3=CC(C4)CC5=NC6=CC(Cl)=CC=C6C(N)=C5C4C3)N=N2
Biological Activity: AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, with IC50s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease[1].
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AChE/BChE-IN-1 | AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, with IC50s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease. | |||||||||||||||||||||
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Keywords
