1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Cholinesterase (ChE)
    nAChR
  3. Galanthamine hydrobromide

Galanthamine hydrobromide (Synonyms: Galantamine hydrobromide)

Cat. No.: HY-A0009 Purity: 99.91%
Handling Instructions

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).

For research use only. We do not sell to patients.

Galanthamine hydrobromide Chemical Structure

Galanthamine hydrobromide Chemical Structure

CAS No. : 1953-04-4

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Customer Review

Based on 7 publication(s) in Google Scholar

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Description

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3].

IC50 & Target

IC50: 0.35 µM (AChE)[3]

In Vitro

Galanthamine hydrobromide is 53-fold selectivity for AChE over butyrylcholinesterase[2].
Galanthamine hydrobromide (25-1000 µM) inhibits both Aβ 1-40 (50 µM) and Aβ 1-42 (50 µM) aggregation[4].
Galanthamine hydrobromide (25-1000 µM) protects against Aβ(1-40) and Aβ(1-42) toxicity in SH-SY5Y cells[4].
Galanthamine hydrobromide also dramatically reduces Aβ(1-40)-induced cellular apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Galanthamine hydrobromide (1.25-2.5 mg/kg; i.p. ) reduces cognitive deficits in APP23 mice[5].
Galanthamine hydrobromide (10 mg/kg; i.g.) displays short elimination half-life of approximately 2 h in wild-type mice[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP23 mice[5]
Dosage: 1.25 mg/kg, 2.5 mg/kg
Administration: Intraperitoneal injection, daily, 1 week
Result: Effectively remedied the spatial learning deficit.
Animal Model: Female 57B1/6J wild type[6]
Dosage: 10 mg/kg
Administration: Oral gavage (Pharmacokinetic Analysis)
Result: Cmax (0.31 µg/mL), t1/2β (1.6 h), AUC0-24h (0.67 µg • h/mL).
Clinical Trial
Molecular Weight

368.27

Formula

C17H22BrNO3

CAS No.
SMILES

O[[email protected]@H]1C[[email protected]@H]2OC3=C4C(CN(C)CC[[email protected]]42C=C1)=CC=C3OC.Br

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (45.27 mM; ultrasonic and warming and heat to 80°C)

DMSO : ≥ 3.7 mg/mL (10.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7154 mL 13.5770 mL 27.1540 mL
5 mM 0.5431 mL 2.7154 mL 5.4308 mL
10 mM 0.2715 mL 1.3577 mL 2.7154 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.93%

References
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Galanthamine hydrobromide
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