1. Neuronal Signaling
    Apoptosis
  2. AChE
    Apoptosis
  3. Galanthamine hydrobromide

Galanthamine hydrobromide (Synonyms: Galantamine hydrobromide)

Cat. No.: HY-A0009 Purity: 99.93%
Handling Instructions

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.

For research use only. We do not sell to patients.

Galanthamine hydrobromide Chemical Structure

Galanthamine hydrobromide Chemical Structure

CAS No. : 1953-04-4

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10 mM * 1  mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 276 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Galanthamine hydrobromide:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChE Galanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Clinical Trial
Molecular Weight

368.27

Formula

C₁₇H₂₂BrNO₃

CAS No.

1953-04-4

SMILES

O[[email protected]@H]1C[[email protected]@H]2OC3=C4C(CN(C)CC[[email protected]]42C=C1)=CC=C3OC.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (67.88 mM; Need ultrasonic)

DMSO : ≥ 3.7 mg/mL (10.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7154 mL 13.5770 mL 27.1540 mL
5 mM 0.5431 mL 2.7154 mL 5.4308 mL
10 mM 0.2715 mL 1.3577 mL 2.7154 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.93%

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Keywords:

GalanthamineGalantamineAChEApoptosisAcetylcholinesteraseInhibitorinhibitorinhibit

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Galanthamine hydrobromide
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HY-A0009
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