1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. AChE
    nAChR
  3. Galanthamine hydrobromide

Galanthamine hydrobromide (Synonyms: Galantamine hydrobromide)

Cat. No.: HY-A0009 Purity: 99.93%
Handling Instructions

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).

For research use only. We do not sell to patients.

Galanthamine hydrobromide Chemical Structure

Galanthamine hydrobromide Chemical Structure

CAS No. : 1953-04-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Galanthamine hydrobromide:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3].

IC50 & Target

IC50: 0.35 µM (AChE)[3]

In Vitro

Galanthamine hydrobromide is selective for AChE rather than butyrylcholinesterase[1].
Galanthamine hydrobromide is 53-fold selectivity for AChE over butyrylcholinesterase[2].
Galanthamine hydrobromide (25-1000 µM) inhibited both Aβ 1-40 (50 µM) and Aβ 1-42 (50 µM) aggregation[4].
Galanthamine hydrobromide (25-1000 µM) protects against Aβ(1-40) and Aβ(1-42) toxicity in SH-SY5Y cells[4].
Galanthamine hydrobromide also dramatically reduced Aβ(1-40)-induced cellular apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Galanthamine hydrobromide (1.25-2.5 mg/kg; i.p. ) reduces cognitive deficits in APP23 mice[5].
Galanthamine hydrobromide (10 mg/kg; i.g.) displays short elimination half-life of approximately 2 h in wild-type mice[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP23 mice[5]
Dosage: 1.25 mg/kg, 2.5 mg/kg
Administration: Intraperitoneal injection, daily, 1 week
Result: Effectively remedied the spatial learning deficit.
Animal Model: Female 57B1/6J wild type[6]
Dosage: 10 mg/kg
Administration: Oral gavage (Pharmacokinetic Analysis)
Result: Cmax (0.31 µg/ml), t1/2β (1.6 h), AUC0-24h (0.67 µg • h/ml).
Clinical Trial
Molecular Weight

368.27

Formula

C₁₇H₂₂BrNO₃

CAS No.

1953-04-4

SMILES

O[[email protected]@H]1C[[email protected]@H]2OC3=C4C(CN(C)CC[[email protected]]42C=C1)=CC=C3OC.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (67.88 mM; Need ultrasonic)

DMSO : ≥ 3.7 mg/mL (10.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7154 mL 13.5770 mL 27.1540 mL
5 mM 0.5431 mL 2.7154 mL 5.4308 mL
10 mM 0.2715 mL 1.3577 mL 2.7154 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.93%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GalanthamineGalantamineAChEnAChRAcetylcholinesteraseNicotinic acetylcholine receptorsAlzheimer'sdisease (AD)neurodegenerativediseaseacetylcholinesteraseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Galanthamine hydrobromide
Cat. No.:
HY-A0009
Quantity:
MCE Japan Authorized Agent: