2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Cholinesterase (ChE) ROS Kinase
  4. AChE/BChE-IN-9

AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB.

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AChE/BChE-IN-9 Chemical Structure

AChE/BChE-IN-9 Chemical Structure

CAS No. : 2761542-55-4

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AChE/BChE-IN-9 Related Antibodies

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Description

AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].

IC50 & Target

IC50: 5.74 μM (AChE), 14.05 μM (BChE)[1]
In Vivo

AChE/BChE-IN-9 (Compound 7a) (0-25 mg/kg) improves spatial memory in cognitive deficit mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

365.38

Formula

C20H19N3O4
CAS No.
SMILES

COC1=C(C=CC(/C=C/C(NCC(NC2=CC=C3NC=CC3=C2)=O)=O)=C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE/BChE-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-92761542-55-4Cholinesterase (ChE)ROS Kinaseneurodegenerative disordersAlzheimer’s diseaseacetylcholinesteraseamyloid-betaantioxidantBBBInhibitorinhibitorinhibit

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