1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. AChE
    ROS
  3. AChE/BChE-IN-9

AChE/BChE-IN-9 

Cat. No.: HY-146399
Handling Instructions

AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB.

For research use only. We do not sell to patients.

AChE/BChE-IN-9 Chemical Structure

AChE/BChE-IN-9 Chemical Structure

CAS No. : 2761542-55-4

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Description

AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].

IC50 & Target

IC50: 5.74 μM (AChE), 14.05 μM (BChE)[1]

In Vivo

AChE/BChE-IN-9 (Compound 7a) (0-25 mg/kg) improves spatial memory in cognitive deficit mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

365.38

Formula

C20H19N3O4

CAS No.
SMILES

COC1=C(C=CC(/C=C/C(NCC(NC2=CC=C3NC=CC3=C2)=O)=O)=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
AChE/BChE-IN-9
Cat. No.:
HY-146399
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