2761542-55-4
Chemical Structure
AChE/BChE-IN-9
- CAS No.: 2761542-55-4
- Formula:C20H19N3O4
- Molecular Weight:365.38
IUPAC Name: (E)-N-(2-((1H-indol-5-yl)amino)-2-oxoethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide
InChIKey: XVKHPTDTSZLRHX-XVNBXDOJSA-N
SMILES: COC1=C(C=CC(/C=C/C(NCC(NC2=CC=C3NC=CC3=C2)=O)=O)=C1)O
Biological Activity: AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].
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AChE/BChE-IN-9 | AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB. | |||||||||||||||||||||
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Keywords
