1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. AChE
    Beta-secretase
    ROS
  3. AChE/BChE/BACE-1-IN-1

AChE/BChE/BACE-1-IN-1 

Cat. No.: HY-147658
Handling Instructions

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential.

For research use only. We do not sell to patients.

AChE/BChE/BACE-1-IN-1 Chemical Structure

AChE/BChE/BACE-1-IN-1 Chemical Structure

CAS No. : 1321361-13-0

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Description

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].

IC50 & Target

IC50: 0.058 μM (hAChE), 0.082 μM (hBChE), 0.115 μM (hBACE-1)[1]

In Vivo

AChE/BChE/BACE-1-IN-1 (Compound 4k) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.38

Formula

C19H21F3N2O

CAS No.
SMILES

FC(F)(OC1=CC=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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AChE/BChE/BACE-1-IN-1
Cat. No.:
HY-147658
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