1321361-13-0
Chemical Structure
AChE/BChE/BACE-1-IN-1
- CAS No.: 1321361-13-0
- Formula:C19H21F3N2O
- Molecular Weight:350.38
IUPAC Name: 1-benzyl-N-(4-(trifluoromethoxy)benzyl)pyrrolidin-3-amine
InChIKey: RLLGGQDQUFVCQL-UHFFFAOYSA-N
SMILES: FC(F)(OC1=CC=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3)F
Biological Activity: AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].
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AChE/BChE/BACE-1-IN-1 | AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential. | |||||||||||||||||||||
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Keywords
