Swertianolin
Based on 1 publication(s) in Google Scholar
Swertianolin is a xanthone glycoside. Swertianolin can be isolated from plants of the Gentianaceae family (e.g., Gentiana campestris and Swertia punicea). Swertianolin inhibits p38 phosphorylation and NF-κB activation, and reduces NO and ROS production. Swertianolin exhibits anti-Helicobacter pylori activity with an IC50 of 6.1 μM and a minimum bactericidal concentration of 91.7 μM. Swertianolin modulates immune function in sepsis. Swertianolin is useful in the research of diseases such as Alzheimer's disease, hepatitis B, Helicobacter pylori infection, and sepsis.
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 23445-00-3
- Formula: C20H20O11
- Molecular Weight:436.37
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Swertianolin
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Biological Activity
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AChE |
Swertianolin (1.6-25 μg/mL; 8 days) suppresses the expression of HBeAg in HepG₂ cells with an IC50 of 8.0 μg/mL[2].
Swertianolin (12.5-200 μM; 24-72 h) significantly reduces the secretion of IL-10, NO, ROS, and arginase in MDSCs, inhibits MDSC proliferation, promotes their differentiation into dendritic cells, and improves T-cell activity by blocking the immunosuppressive effect of MDSCs[3].
Swertianolin exhibits anti-Helicobacter pylori activity with an IC50 of 6.1 μM and a minimum bactericidal concentration of 91.7 μM[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old C57BL/6 mice (weight 25-30 g) with sepsis induced by cecal ligation and puncture (CLP) [5]
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Dosage:12.5 μg/kg
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Administration:intraperitoneal injection; 7 days (from the 5th day after CLP surgery)
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Result:Reduced the proportion of MDSCs in the marrow (58.81% vs 87.89% in normal saline group) and spleen (28.60% vs 48.02% in normal saline group).
Increased CD4+ T cells in the spleen (28.99% vs 20.44% in normal saline group).
Decreased plasma concentrations of IL-10, NO, ROS, and arginase; reduced lung damage and improved survival rate after Legionella pneumophila challenge by inhibiting p38 phosphorylation and NF-κB activation.
Chemical Information
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CAS No. 23445-00-3
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Appearance Solid
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Molecular Weight 436.37
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Formula C20H20O11
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Color White to yellow
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SMILES
O=C1C2=C(OC3=C1C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC=C3O)C=C(OC)C=C2O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvent & Solubility
DMSO : 25 mg/mL (57.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Urbain A, et al. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004 Oct;70(10):1011-4. [Content Brief]
[3]. Ren Z, et al. Swertianolin ameliorates immune dysfunction in sepsis via blocking the immunosuppressive function of myeloid- derived suppressor cells. Eur J Histochem. 2021 Sep 1;65(3):3292. [Content Brief]
[4]. Suzuki R, et al. Anti-Helicobacter pylori activity of swertianolin, isolated from swertia herb. J Nat Med. 2023 Sep;77(4):1005-1008. [Content Brief]
[5]. Tang H, et al. Swertianolin regulates immunosuppression of myeloid suppressor cells in septic mice by inhibiting NF-κB and P38 signaling. Transpl Immunol. 2025 May;90:102217. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2916 mL | 11.4582 mL | 22.9163 mL | 57.2908 mL |
| 5 mM | 0.4583 mL | 2.2916 mL | 4.5833 mL | 11.4582 mL | |
| 10 mM | 0.2292 mL | 1.1458 mL | 2.2916 mL | 5.7291 mL | |
| 15 mM | 0.1528 mL | 0.7639 mL | 1.5278 mL | 3.8194 mL | |
| 20 mM | 0.1146 mL | 0.5729 mL | 1.1458 mL | 2.8645 mL | |
| 25 mM | 0.0917 mL | 0.4583 mL | 0.9167 mL | 2.2916 mL | |
| 30 mM | 0.0764 mL | 0.3819 mL | 0.7639 mL | 1.9097 mL | |
| 40 mM | 0.0573 mL | 0.2865 mL | 0.5729 mL | 1.4323 mL | |
| 50 mM | 0.0458 mL | 0.2292 mL | 0.4583 mL | 1.1458 mL |
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