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Cat. No.: HY-190927

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NLRP3 ligand 2

NLRP3 ligand 2 (compound R3) is an NLRP3 ligand that can be used to synthesize the PROTAC NLRP3 ATTEC degrader-1 (HY-190873).

For research use only. We do not sell to patients.

Formula: C₂₀H₁₈ClN₃O₃
Molecular Weight:383.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

NLRP3 ligand 2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

NLRP3 ligand 2 (compound R3) is an NLRP3 ligand that can be used to synthesize the PROTAC NLRP3 ATTEC degrader-1 (HY-190873)^[1].

IC₅₀ & Target

^[1]

NLRP3

All NOD-like Receptor (NLR) Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 383.83
Formula C₂₀H₁₈ClN₃O₃
SMILES

O=C(C1=CC=C(C=C1)[C@H](C)NC2=NN=C(C=C2C)C3=CC=C(C=C3O)Cl)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zheng X, et al. Beyond Inhibition: Targeted Degradation of NLRP3 by Autophagy-Tethering Bifunctional Compounds as a Therapy for Inflammatory Bowel Disease. Journal of medicinal chemistry. 2026 Oct 22;69(20):24400-24419.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NLRP3 ligand 2

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NLRP3 ligand 2 Related Classifications

HY-190927 Related Classifications

Bioz

Keywords

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