Oxidized ATP trisodium salt
Based on 1 Customer Validation
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 71997-40-5
- Formula: C10H11N5Na3O13P3
- Molecular Weight:571.11
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All P2X Receptor Isoforms
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Biological Activity
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NLRP3 inflammasome |
P2X7 Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Induced mouse experimental autoimmune uveitis (EAU)[2]
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Dosage:300 μg/mouse
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Administration:i.p.
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Result:Showed almost undetected EAU, as shown by fundoscopic and pathologic examination.
Decreased serum IL-17 level.
Mitigated the autoreactive T cell response.
Chemical Information
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CAS No. 71997-40-5
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Appearance Solid
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Molecular Weight 571.11
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Formula C10H11N5Na3O13P3
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Color White to off-white
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SMILES
O=P(O)(O[Na])OP(OP(OC[C@H](C=O)O[C@@H](N1C2=NC=NC(N)=C2N=C1)C=O)(O[Na])=O)(O[Na])=O
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Synonyms
oATP trisodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (87.55 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40. [Content Brief]
[2]. Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7510 mL | 8.7549 mL | 17.5098 mL | 43.7744 mL |
| 5 mM | 0.3502 mL | 1.7510 mL | 3.5020 mL | 8.7549 mL | |
| 10 mM | 0.1751 mL | 0.8755 mL | 1.7510 mL | 4.3774 mL | |
| 15 mM | 0.1167 mL | 0.5837 mL | 1.1673 mL | 2.9183 mL | |
| 20 mM | 0.0875 mL | 0.4377 mL | 0.8755 mL | 2.1887 mL | |
| 25 mM | 0.0700 mL | 0.3502 mL | 0.7004 mL | 1.7510 mL | |
| 30 mM | 0.0584 mL | 0.2918 mL | 0.5837 mL | 1.4591 mL | |
| 40 mM | 0.0438 mL | 0.2189 mL | 0.4377 mL | 1.0944 mL | |
| 50 mM | 0.0350 mL | 0.1751 mL | 0.3502 mL | 0.8755 mL | |
| 60 mM | 0.0292 mL | 0.1459 mL | 0.2918 mL | 0.7296 mL | |
| 80 mM | 0.0219 mL | 0.1094 mL | 0.2189 mL | 0.5472 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Oxidized ATP trisodium salt Related Classifications
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