2. NF-κB Immunology/Inflammation Membrane Transporter/Ion Channel
  3. NF-κB NOD-like Receptor (NLR) Sodium Channel
  4. Articaine

Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway.

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Articaine Chemical Structure

Articaine Chemical Structure

CAS No. : 23964-58-1

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Description

Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3].

IC50 & Target

NF-ĸB, NLRP3, sodium channel[2][3]
Clinical Trial
Molecular Weight

284.37

Formula

C13H20N2O3S
CAS No.
SMILES

O=C(C(C)NCCC)NC(C(C)=CS1)=C1C(OC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Articaine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Articaine23964-58-1Hoe-045Hoe045Hoe 045NF-κBNOD-like Receptor (NLR)Sodium ChannelNuclear factor-κBNuclear factor-kappaBNa channelsNa+ channelsAmidepain reliefkidney injuryLPSInhibitorinhibitorinhibit

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