2. Apoptosis Immunology/Inflammation Stem Cell/Wnt MAPK/ERK Pathway Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Epigenetics
  3. Pyroptosis NOD-like Receptor (NLR) ERK FGFR AMPK
  4. Kanglexin

Kanglexin is an orally active and novel anthraquinone compound. Kanglexin inhibits NLRP3 inflammatory body activation and cell pyroptosis, and has a cardioprotective effect. Kanglexin promotes angiogenesis through FGFR1/ERK signaling pathway and accelerates diabetic wound healing. In addition, Kanglexin has the effect of lipid-lowering and inhibiting the dedifferentiation of vascular smooth muscle cells, and can be used in the study of hyperlipidemia, fatty liver and atherosclerosis.

For research use only. We do not sell to patients.

Kanglexin

Kanglexin Chemical Structure

CAS No. : 2228847-12-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

Kanglexin Related Antibodies

Top Publications Citing Use of Products

View All NOD-like Receptor (NLR) Isoform Specific Products:

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NLRP3 NLRP1 NOD1 NOD2

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ERK ERK1 ERK2 ERK5 ERK8

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

  • Biological Activity

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  • Customer Review

Description

Kanglexin is an orally active and novel anthraquinone compound. Kanglexin inhibits NLRP3 inflammatory body activation and cell pyroptosis, and has a cardioprotective effect. Kanglexin promotes angiogenesis through FGFR1/ERK signaling pathway and accelerates diabetic wound healing. In addition, Kanglexin has the effect of lipid-lowering and inhibiting the dedifferentiation of vascular smooth muscle cells, and can be used in the study of hyperlipidemia, fatty liver and atherosclerosis[1][2][3][4].

IC50 & Target[1]

NLRP3

 

In Vitro

Kanglexin (10-20 μM; 24 h) inhibits pyroptosis of cardiomyocytes treated with hypoxia or LPS (HY-D1056)[1].
Kanglexin (5-20 μM; 24 h) reduces lipid levels in Oleic acid (HY-N1446) treated HepG2 cells through AMPK/SREGBP-2/PCSK9/LDLR signaling pathway[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kanglexin Related Antibodies

Western Blot Analysis[1]

Cell Line: LPS (HY-D1056) treated neonatal mouse ventricular cardiomyocytes
Concentration: 10 μM
Incubation Time: 24 h
Result: Inhibited the levels of NLRP3 and the pyroptosis-related proteins mature IL-1β and IL-18.
In Vivo

Kanglexin (20-40 mg/kg; oral gavage; 7 days) has an ameliorative effect in the myocardial infarction mouse model[1].
Kanglexin (20-80 mg/kg; oral administration; 2 weeks) has an ameliorative effect in the hyperlipidemia rat model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice aged 8 weeks old (20 ± 2 g) with myocardial infarction (MI) model[1]
Dosage: 20 and 40 mg/kg
Administration: Oral gavage (i.g.); 7 days
Result: Reduced myocardial injury in MI mice.
Effectively inhibited pyroptosis processes in the mouse hearts with MI.
Attenuated the activation of the NLRP3 inflammasome upon MI in mouse hearts.
Animal Model: High fat diet treated Sprague-Dawley rats[2]
Dosage: 20, 40 and 80 mg/kg
Administration: Oral administration (p.o.); 2 weeks
Result: Had prominent effects on reducing blood lipids, hepatic lipid accumulation, body weight and the ratio of liver weight/body weight.
Molecular Weight

398.36

Formula

C21H18O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C(C3=C(C=C(C)C=C13)O)=O)C(O)=CC(OC(CCC(OCC)=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (62.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5103 mL 12.5515 mL 25.1029 mL
5 mM 0.5021 mL 2.5103 mL 5.0206 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5103 mL 12.5515 mL 25.1029 mL 62.7573 mL
5 mM 0.5021 mL 2.5103 mL 5.0206 mL 12.5515 mL
10 mM 0.2510 mL 1.2551 mL 2.5103 mL 6.2757 mL
15 mM 0.1674 mL 0.8368 mL 1.6735 mL 4.1838 mL
20 mM 0.1255 mL 0.6276 mL 1.2551 mL 3.1379 mL
25 mM 0.1004 mL 0.5021 mL 1.0041 mL 2.5103 mL
30 mM 0.0837 mL 0.4184 mL 0.8368 mL 2.0919 mL
40 mM 0.0628 mL 0.3138 mL 0.6276 mL 1.5689 mL
50 mM 0.0502 mL 0.2510 mL 0.5021 mL 1.2551 mL
60 mM 0.0418 mL 0.2092 mL 0.4184 mL 1.0460 mL
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Kanglexin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kanglexin2228847-12-7PyroptosisNOD-like Receptor (NLR)ERKFGFRAMPKExtracellular signal regulated kinasesFibroblast growth factor receptorAMP-activated protein kinasemyocardial infarction modelhyperlipidemia modelcardiomyocytesHepG2 cellsInhibitorinhibitorinhibit

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