1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. QS-21

QS-21 (Synonyms: Stimulon)

Cat. No.: HY-101092
Handling Instructions

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.

For research use only. We do not sell to patients.

QS-21 Chemical Structure

QS-21 Chemical Structure

CAS No. : 141256-04-4

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Description

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].

IC50 & Target

NLRP3 inflammasome

 

In Vivo

Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1990.13

Formula

C₉₂H₁₄₈O₄₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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QS-21
Cat. No.:
HY-101092
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