1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. QS-21

QS-21  (Synonyms: Stimulon)

Cat. No.: HY-101092 Purity: ≥90.0%
COA Handling Instructions

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.

For research use only. We do not sell to patients.

QS-21 Chemical Structure

QS-21 Chemical Structure

CAS No. : 141256-04-4

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 720 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2150 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].

IC50 & Target

NLRP3 inflammasome

 

In Vivo

Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1990.13

Formula

C92H148O46

CAS No.
SMILES

O=C([[email protected]]1(CCC(C)(C)C2)[[email protected]]2([H])C3=CC[[email protected]@]4([H])[[email protected]@](C)(CC[[email protected]]5([H])[[email protected]@]4(CC[[email protected]](O[[email protected]@](O[[email protected]](C(O)=O)[[email protected]@H](O)[[email protected]@H]6O[[email protected]@](OC[[email protected]@H](O)[[email protected]@H]7O)([H])[[email protected]@H]7O)([H])[[email protected]@H]6O[[email protected]]([[email protected]@H]([[email protected]@H](O)[[email protected]]8O)O)([H])O[[email protected]@H]8CO)[[email protected]@]5(C)C=O)C)[[email protected]]3(C)C[[email protected]]1O)O[[email protected]](O[[email protected]](C)[[email protected]](OC(C[[email protected]@H](O)C[[email protected]]([[email protected]@H](C)CC)([H])OC(C[[email protected]@H](O)C[[email protected]]([[email protected]@H](C)CC)([H])O[[email protected]@H]9O[[email protected]@H](CO)[[email protected]](O)[[email protected]]9O)=O)=O)[[email protected]@H]%10O)[[email protected]@H]%10O[[email protected]@](O[[email protected]@H](C)[[email protected]](O[[email protected]@](OC[[email protected]@H](O)[[email protected]@H]%11O[[email protected]@](OC[[email protected]]%12(O)CO)([H])[[email protected]@H]%12O)([H])[[email protected]@H]%11O)[[email protected]]%13O)([H])[[email protected]@H]%13O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (50.25 mM; Need ultrasonic)

H2O : 50 mg/mL (25.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5025 mL 2.5124 mL 5.0248 mL
5 mM 0.1005 mL 0.5025 mL 1.0050 mL
10 mM 0.0502 mL 0.2512 mL 0.5025 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.26 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.26 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥90.0%

References
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Product Name:
QS-21
Cat. No.:
HY-101092
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