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Cat. No.: HY-160757A

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NLRP3 modulator 7 TFA

NLRP3 modulator 7 (Compound 17B) TFA is a NLRP3 inflammasome modulator. NLRP3 modulator 7 TFA inhibits LPS (HY-D1056)-induced IL-1β release in fresh human whole blood. NLRP3 modulator 7 TFA can be used in studies related to NLRP3 inflammasome activation and innate immune signaling.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₃F₆N₃O₄
Molecular Weight:495.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NLRP3 modulator 7 TFA Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

IC₅₀ & Target

NLRP3 inflammasome

IL-1b

< 500 nM (IC₅₀)

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

In Vitro

NLRP3 modulator 7 (Compound 17B) TFA inhibits IL-1β production in immune cells stimulated via NLRP3 inflammasome activation with an IC₅₀ < 500 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 495.42
Formula C₂₁H₂₃F₆N₃O₄
SMILES

OC1=C(C2=C(C=C(N=N2)[C@@H]([C@@]3([H])CN(CCC3)C)O)C)C=CC(C(F)(F)F)=C1.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Collins J, et al. NLRP3 modulators. WO 2023/178099 A1. World Intellectual Property Organization. 2023-09-21.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NLRP3 modulator 7 TFA

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms