1. Protein Tyrosine Kinase/RTK
  2. Src
    Syk

MNS (Synonyms: NSC 170724; 5-(2-Nitrovinyl)benzodioxole)

Cat. No.: HY-78263
Handling Instructions

MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.

For research use only. We do not sell to patients.
MNS Chemical Structure

MNS Chemical Structure

CAS No. : 1485-00-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 g $50 In-stock
10 g   Get quote  
50 g   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1] IC50:29.3 (src), 2.5 uM (syk); [1] In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 5.1771 mL 25.8853 mL 51.7706 mL
5 mM 1.0354 mL 5.1771 mL 10.3541 mL
10 mM 0.5177 mL 2.5885 mL 5.1771 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

193.16

Formula

C₉H₇NO₄

CAS No.

1485-00-3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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MNS
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