1. Protein Tyrosine Kinase/RTK
  2. Src
    Syk
  3. MNS

MNS (Synonyms: NSC 170724; 5-(2-Nitrovinyl)benzodioxole)

Cat. No.: HY-78263 Purity: 99.23%
Handling Instructions

MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.

For research use only. We do not sell to patients.

MNS Chemical Structure

MNS Chemical Structure

CAS No. : 1485-00-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg USD 80 In-stock
Estimated Time of Arrival: December 31
500 mg USD 160 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1] IC50:29.3 (src), 2.5 uM (syk); [1] In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]

Molecular Weight

193.16

Formula

C₉H₇NO₄

CAS No.

1485-00-3

SMILES

O=[N+]([O-])/C=C/C1=CC(OCO2)=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (258.85 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1771 mL 25.8853 mL 51.7706 mL
5 mM 1.0354 mL 5.1771 mL 10.3541 mL
10 mM 0.5177 mL 2.5885 mL 5.1771 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (12.94 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
MNS
Cat. No.:
HY-78263
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