1. Protein Tyrosine Kinase/RTK
  2. Src
    Syk
  3. MNS

MNS (Synonyms: NSC 170724; 5-(2-Nitrovinyl)benzodioxole)

Cat. No.: HY-78263
Handling Instructions

MNS (NSC 170724), the beta-nitrostyrene derivative, is a potent tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS inhibits Src, Syk, and FAK with IC50 of 27.3, 2.8, and 97.6 μM, respectively.

For research use only. We do not sell to patients.

MNS Chemical Structure

MNS Chemical Structure

CAS No. : 1485-00-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg USD 80 In-stock
Estimated Time of Arrival: December 31
500 mg USD 160 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MNS (NSC 170724), the beta-nitrostyrene derivative, is a potent tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS inhibits Src, Syk, and FAK with IC50 of 27.3, 2.8, and 97.6 μM, respectively[1][2].

Molecular Weight

193.16

Formula

C₉H₇NO₄

CAS No.

1485-00-3

SMILES

O=[N+]([O-])/C=C/C1=CC(OCO2)=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (258.85 mM; Need ultrasonic)

H2O : 0.67 mg/mL (3.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1771 mL 25.8853 mL 51.7706 mL
5 mM 1.0354 mL 5.1771 mL 10.3541 mL
10 mM 0.5177 mL 2.5885 mL 5.1771 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (12.94 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MNSNSC 170724 5-(2-Nitrovinyl)benzodioxoleNSC170724NSC-170724SrcSykSpleen tyrosine kinaseGPIIb/IIIaactivationplateletaggregationthrombinbeta-nitrostyrenederivativeInhibitorinhibitorinhibit

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MNS
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