TBKBP1 - TBK1 binding protein 1 Gene

Also Known as SINTBAD; ProSAPiP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9755

About TBKBP1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,694,063-47,712,063 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 4.8), fat (RPKM 4.5) and 25 other tissues.

Summary

TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

TBKBP1 Products (3)

mRNA Protein Name
NM_001394755.1 NP_001381684.1 TANK-binding kinase 1-binding protein 1
NM_001394756.1 NP_001381685.1 TANK-binding kinase 1-binding protein 1
NM_014726.2 NP_055541.1 TANK-binding kinase 1-binding protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14743216 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBKBP1 Protein Structure

TBD

TBD: TBD domain (286 - 341)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 615 a.a.
Protein Preferred Names Protein Names

TANK-binding kinase 1-binding protein 1

TBKBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TBKBP1 A7MCY6 RB1CC1 Homo sapiens Q8TDY2
Anti Tag CoIP
21903422
Intra
TBKBP1 A7MCY6 IKBKE Homo sapiens Q14164
Anti Bait CoIP
17568778
Intra
TBKBP1 A7MCY6 IKBKE Homo sapiens Q14164
Lumier
21931555
Intra
TBKBP1 A7MCY6 IKBKE Homo sapiens Q14164
Anti Tag CoIP
21903422
Intra
TBKBP1 A7MCY6 TBK1 Homo sapiens Q9UHD2
Lumier
21931555
Intra
TBKBP1 A7MCY6 TBK1 Homo sapiens Q9UHD2
TAP
14743216
Intra
TBKBP1 A7MCY6 TBK1 Homo sapiens Q9UHD2
Anti Bait CoIP
17568778
Intra
TBKBP1 A7MCY6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
17568778
Intra
TBKBP1 A7MCY6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
21903422
Intra
TBKBP1 A7MCY6 AGO2 Homo sapiens Q9UKV8
Anti Tag CoIP
21903422
Intra
TBKBP1 A7MCY6 APBA3 Homo sapiens O96018
Anti Tag CoIP
21903422
Cross
TBKBP1 A7MCY6 OPG029 vaccinia virus P17362
Anti Tag CoIP
21931555
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14260 TBKBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TBKBP1 RGD RGD:631328
Felis catus TBKBP1 VGNC VGNC:65998
Canis familiaris TBKBP1 VGNC VGNC:47161
Macaca mulatta TBKBP1 VGNC VGNC:78241
Bos taurus TBKBP1 VGNC VGNC:35657
Mus musculus TBKBP1 MGD MGI:1920424
Others TBKBP1 NCBI