PROTAC TBK1 degrader-2
Based on 2 publication(s) in Google Scholar
PROTAC TBK1 degrader-2 is a potent PROTAC degrader of serine/threonine kinase TANK-binding kinase 1 (TBK1) (DC50=15 nM; Kd=4.6 nM) with a maximum efficiency of 96%. PROTAC TBK1 degrader-2 also targets to IkB kinase IKKε (IC50=8.7 nM), with low selectivity over TBK1 (IC50=1.3 nM).
(Pink: TBK1 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.22%
- CAS No.: 2052306-13-3
- Formula: C53H74BrN9O9S
- Molecular Weight:1093.18
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PROTAC TBK1 degrader-2
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Biological Activity
IC50: 1.3 nM (TBK1), 8.7 nM (IKKε)[1]
PROTAC TBK1 degrader-2 (compound 3i) (100 nM) mediates degradation of TBK1 abrogated by VHL ligand 2 (10 μM) or proteasome inhibitor Carfilzomib (HY-10455) (100 nM)[1].
PROTAC TBK1 degrader-2 (0-3 μM) exhibits poor selectivity for TBK1 over IKKε (IC50 of 1.3 nM vs 8.7 nM), but has no effect on the levels of IKKε, at concentrations of more than 50-fold above its TBK1 DC50[1].
PROTAC TBK1 degrader-2 (100 nM; 300 M; 72 h) is not synthetically lethal in K-Ras mutant versus wild type cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K-Ras mutant cell lines (H23, A549, and H1792) and K-Rras wild type cell lines (H2110 and HCC827)
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Concentration:100 nM, 300 nM
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Incubation Time:72 hours
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Result:Lacked synthetically lethality in K-Ras mutant versus wild type cells.
Chemical Information
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CAS No. 2052306-13-3
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Appearance Solid
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Molecular Weight 1093.18
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Formula C53H74BrN9O9S
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Color White to off-white
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SMILES
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCCOCCCCOCCCOC4=CC=C(NC5=NC=C(Br)C(NCCCN(C(C6CCC6)=O)C)=N5)C=C4)=O)=O)C[C@H](O)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Sci
E3 ligase UHRF2 hijacks nuclear TBK1 to epigenetically repress type I interferons expression. [Abstract]2026 May 18;22(10):5385-5398. PMID: 42212328 -
Solvent & Solubility
DMSO : 110 mg/mL (100.62 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9148 mL | 4.5738 mL | 9.1476 mL | 22.8691 mL |
| 5 mM | 0.1830 mL | 0.9148 mL | 1.8295 mL | 4.5738 mL | |
| 10 mM | 0.0915 mL | 0.4574 mL | 0.9148 mL | 2.2869 mL | |
| 15 mM | 0.0610 mL | 0.3049 mL | 0.6098 mL | 1.5246 mL | |
| 20 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1435 mL | |
| 25 mM | 0.0366 mL | 0.1830 mL | 0.3659 mL | 0.9148 mL | |
| 30 mM | 0.0305 mL | 0.1525 mL | 0.3049 mL | 0.7623 mL | |
| 40 mM | 0.0229 mL | 0.1143 mL | 0.2287 mL | 0.5717 mL | |
| 50 mM | 0.0183 mL | 0.0915 mL | 0.1830 mL | 0.4574 mL | |
| 60 mM | 0.0152 mL | 0.0762 mL | 0.1525 mL | 0.3812 mL | |
| 80 mM | 0.0114 mL | 0.0572 mL | 0.1143 mL | 0.2859 mL | |
| 100 mM | 0.0091 mL | 0.0457 mL | 0.0915 mL | 0.2287 mL |
PROTAC TBK1 degrader-2 Related Classifications
HY-112557 Related Classifications
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