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GSK8612 

Cat. No.: HY-111941
Handling Instructions

GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.

For research use only. We do not sell to patients.

GSK8612 Chemical Structure

GSK8612 Chemical Structure

Size Price Stock
5 mg USD 180 Get quote
10 mg USD 280 Get quote
25 mg USD 590 Get quote
50 mg USD 950 Get quote

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  • Biological Activity

  • Technical Information

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  • References

Description

GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1[1].

IC50 & Target

pIC50: 6.8 (recombinant TBK1)[1].

In Vitro

GSK8612 inhibits toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of interferon beta (IFN) in response to dsDNA and cGAMP, the natural ligand for STING[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

520.33

Formula

C₁₇H₁₇BrF₃N₇O₂S

SMILES

NS(C1=CC=C(CNC2=C(Br)C=NC(NC3=CN(CC(F)(F)F)N=C3C)=N2)C=C1)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
GSK8612
Cat. No.:
HY-111941
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GSK8612

Cat. No.: HY-111941