2. Gene
  3. GMEB1 - glucocorticoid modulatory element binding protein 1 Gene

GMEB1 - glucocorticoid modulatory element binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PIF96; P96PIF

Gene ID: 10691 | Gene type: protein coding

About GMEB1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,668,229-28,719,353 (from NCBI)

This gene has 4 transcripts (splice variants), 250 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the Glucocorticoid Receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]

GMEB1 Products(3)

mRNA Protein Name
NM_001319674.2 NP_001306603.1 glucocorticoid modulatory element-binding protein 1 isoform 2
NM_006582.4 NP_006573.2 glucocorticoid modulatory element-binding protein 1 isoform 1
NM_024482.3 NP_077808.1 glucocorticoid modulatory element-binding protein 1 isoform 2

GMEB1 Protein Structure

SAND

SAND: SAND domain (88 - 166)

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  • 573 a.a.
Protein Preferred Names Protein Names

glucocorticoid modulatory element-binding protein 1

DNA-binding protein p96PIF

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05516 GMEB1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GMEB1 VGNC VGNC:29432
Canis familiaris GMEB1 VGNC VGNC:41286
Mus musculus GMEB1 MGD MGI:2135604
Felis catus GMEB1 VGNC VGNC:62605
Rattus norvegicus GMEB1 RGD RGD:1563208
Macaca mulatta GMEB1 VGNC VGNC:99963