GMEB1 - glucocorticoid modulatory element binding protein 1 Gene

Also Known as PIF96; P96PIF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10691

About GMEB1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,668,229-28,719,353 (from NCBI)

This gene has 4 transcripts (splice variants), 250 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the Glucocorticoid Receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]

GMEB1 Products (3)

mRNA Protein Name
NM_001319674.2 NP_001306603.1 glucocorticoid modulatory element-binding protein 1 isoform 2
NM_006582.4 NP_006573.2 glucocorticoid modulatory element-binding protein 1 isoform 1
NM_024482.3 NP_077808.1 glucocorticoid modulatory element-binding protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp27 protein binding IPI
IPI: Inferred from physical interaction
10386584 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10386584 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10386584 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10894151 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10386584 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMEB1 Protein Structure

SAND

SAND: SAND domain (88 - 166)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 573 a.a.
Protein Preferred Names Protein Names

glucocorticoid modulatory element-binding protein 1

  • DNA-binding protein p96PIF

GMEB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GMEB1 Q9Y692 GMEB2 Homo sapiens Q9UKD1
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

GMEB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83197 GMEB1 Antibody (YA2942) WB, IP Human
HY-P83197A GMEB1 Antibody (YA2942)(PBS only) WB, IP Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05516 GMEB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GMEB1 VGNC VGNC:29432
Canis familiaris GMEB1 VGNC VGNC:41286
Mus musculus GMEB1 MGD MGI:2135604
Felis catus GMEB1 VGNC VGNC:62605
Rattus norvegicus GMEB1 RGD RGD:1563208
Macaca mulatta GMEB1 VGNC VGNC:99963
Others GMEB1 NCBI