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CCW16 is the covalent ligand for the E3 ubiquitin ligase RNF4. CCW16 can be used in the synthesis of protein degraders.

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CCW16 Chemical Structure

CCW16 Chemical Structure

CAS No. : 2361138-33-0

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Description

CCW16 is the covalent ligand for the E3 ubiquitin ligase RNF4. CCW16 can be used in the synthesis of protein degraders[1].

Molecular Weight

381.85

Formula

C22H20ClNO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(CC1=CC=CC=C1)C2=CC=C(OC3=CC=C(OC)C=C3)C=C2)CCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (65.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6188 mL 13.0941 mL 26.1883 mL
5 mM 0.5238 mL 2.6188 mL 5.2377 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6188 mL 13.0941 mL 26.1883 mL 65.4707 mL
5 mM 0.5238 mL 2.6188 mL 5.2377 mL 13.0941 mL
10 mM 0.2619 mL 1.3094 mL 2.6188 mL 6.5471 mL
15 mM 0.1746 mL 0.8729 mL 1.7459 mL 4.3647 mL
20 mM 0.1309 mL 0.6547 mL 1.3094 mL 3.2735 mL
25 mM 0.1048 mL 0.5238 mL 1.0475 mL 2.6188 mL
30 mM 0.0873 mL 0.4365 mL 0.8729 mL 2.1824 mL
40 mM 0.0655 mL 0.3274 mL 0.6547 mL 1.6368 mL
50 mM 0.0524 mL 0.2619 mL 0.5238 mL 1.3094 mL
60 mM 0.0436 mL 0.2182 mL 0.4365 mL 1.0912 mL
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CCW16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCW162361138-33-0CCW 16CCW-16OthersE3 ubiquitin ligaseRNF4Inhibitorinhibitorinhibit

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